Indications

Hypertension, Heart Failure

Contraindication

Concomitant use w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min). Severe hepatic impairment. Pregnancy.

Special Precautions

Volume-depleted patients including patients on high-dose diuretics. Patients w/ bilateral renal artery stenosis , aortic or mitral stenosis. Renal and mild to moderate hepatic impairment. Lactation. Monitoring Parameters Monitor BP, electrolytes and renal function.

Side Effects

Upper resp infection, nasal congestion, sinusitis, headache, dizziness, back pain, leg pain, muscle cramps, asthenia or fatigue, neutropenia, chest pain, cough, bronchitis, UTI, diarrhoea, gastritis, anaemia, hypoglycaemia, diabetic vascular disease, cataracts, cellulitis, hyperkalaemia, myalgia, arthralgia, hypotension, muscular weakness, hypoaesthesia, infection, knee pain. Rarely, pruritus, rash, urticaria, angioedema, elevated liver enzyme values, rhabdomyolysis.

Drug Interactions

May decrease plasma levels / fluconazole and rifampicin. May increase serum lithium levels and toxicity. May antagonise hypotensive effect and increase risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes.

Route of Administration

Oral

Dosage

As directed by the physician