Indications

Heartburn, Gastroesophageal reflux disease (Acid reflux), Peptic ulcer disease

Contraindication

Concomitant use w/ rilpivirine, atazanavir and nelfinavir. Lactation.

Special Precautions

Gastric malignancy should be ruled out. Consider Zn++ supplementation during IV therapy in patients who are prone to Zn++ deficiency. Pregnancy. Monitoring Parameters Monitor Mg levels prior to initiation and periodically during prolonged use.

Side Effects

Increased risk of Clostridium difficile-associated diarrhoea (CDAD). Headache, dizziness, nausea, vomiting, abdominal pain, flatulence, diarrhoea, constipation, dyspepsia, arthralgia, insomnia, rhinitis, inj site reaction (e.g. thrombophlebitis and abscess). Long-term treatment may lead to atrophic gastritis, symptomatic and asymptomatic hypomagnesaemia, cyanocobalamin malabsorption, and increased risk of osteoporosis-related fracture.

Drug Interactions

Increased risk of digoxin-induced cardiotoxic effects. Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time of warfarin. May increase serum concentration of methotrexate and saquinavir. Delayed absorption and decreased bioavailability w/ sucralfate. Decreased absorption of ketoconazole, itraconazole.

Route of Administration

Oral, Injection

Dosage

As directed by the physician