Indications

Antibiotic

Contraindication

Hypersensitivity to penicillins.

Special Precautions

Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, H/o convulsions, lactation.

Side Effects

GI upsets, rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely), increased incidence of phlebitis with IV use.

Drug Interactions

Failure of OC may occur, loss of potency of cloxacillin in soln. reported with erythromycin, gentamicin, kanamycin, colistin, oxytetracycline, chlorpromazine, Vit.C, & polymyxin B sulphate. Products containing cloxacillin should not be added to IV lipids, blood products, protein hydrolysates or other proteinaceous fluids. Chloramphenicol & tetracycline antagonise bactericidal effect of penicillins. Probenecid prolongs serum drug concentration; Sulfonamides & aspirin inhibit serum protein binding of cloxacillin, thereby increasing serum-free drug levels.

Route of Administration

Oral

Dosage

As directed by the physician