Indications

Allergic and inflammatory disorders, Poorly controlled, moderate to severe asthma, Nephrotic syndrome, Rheumatoid arthritis, Multiple sclerosis, Infantile spasms, Idiopathic thrombocytopenic purpura, Intra-articular Joint inflammations, Conjunctivitis, Ot

Contraindication

Live vaccines; herpes simplex keratitis, systemic infections.

Special Precautions

Patients with hypothyroidism, cirrhosis, ulcerative colitis, CHF, convulsive disorders, thrombophlebitis, peptic ulcer, elderly. DM, hypertension, psychological disturbances, osteoporosis; pregnancy, lactation. Adrenal suppression and infection. May cause irreversible growth retardation, glaucoma, corneal perforation. Topical: Broken or infected skin. Not to be applied over large areas under occlusive dressings.

Side Effects

Cushing's syndrome and growth retardation in childn; osteoporosis, fractures. Peptic ulceration; glaucoma, cataracts; hyperglycaemia, pancreatitis; increased appetite, obesity. Topical: Thinning and atrophy, systemic absorption with prolonged use over large surface, broken skin or under occlusive dressing. Rash, allergic reactions, pruritus. Intradermal/Intralesional: Local hypopigmentation of hyperpigmented lesions. Ophthalmic: Raised IOP and reduced visual function.

Drug Interactions

Increased requirement of insulin and oral hypoglycaemics. Actions blunted by barbiturates, phenytoin, rifampicin. Increased bioavailability with estrogens and oral contraceptives. Increases plasma salicylate levels. Increased risk of convulsions when used with ciclosporin, increased clearance by carbimazole or carbamazepine. Increased risk of GI bleeding and ulceration when used with NSAIDs. May decrease methotrexate clearance.

Route of Administration

Oral, Intramuscular, Drops

Dosage

As directed by the physician