Indications

Antibiotic

Contraindication

Hypersensitivity to ceftriaxone or other cephalosporins. Neonates <41 wk corrected gestational age; neonates >41 wk corrected gestational age w/ jaundice, hypoalbuminaemia, or acidosis; hyperbilirubinaemic neonates esp prematures. Concomitant treatment w/ IV Ca (including TPN containing Ca) in neonates >41 wk corrected gestational age.

Special Precautions

Patient w/ history of penicillin allergy, history of GI disease esp colitis, gallbladder disease. Renal or hepatic impairment. Pregnancy and lactation. Monitoring Parameters Perform CBC at regular intervals during prolonged treatment. Monitor prothrombin time, hepatic and renal function. Observe for signs and symptoms of anaphylaxis.

Side Effects

Diarrhoea, nausea, vomiting; neutropenia, eosinophilia, anaemia, rash, pruritus, fever, chills, increased serum concentrations of AST, ALT, BUN; local reactions (e.g. pain, induration, ecchymosis, tenderness at inj site). Rarely, pancreatitis, hypoprothrombinaemia.

Drug Interactions

May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.

Route of Administration

Intramuscular

Dosage

As directed by the physician