Indications

Seasonal allergic rhinitis, Chronic idiopathic urticaria

Contraindication

End-stage renal disease (CrCl <10 mL/min) or undergoing haemodialysis. Childn (6 mth to 11 yr) w/ renal impairment.

Special Precautions

Epileptic patients and patients at risk of convulsions. Renal impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CrCl prior to treatment for dosage adjustment.

Side Effects

Somnolence, dizziness, fatigue, dry mouth, pharyngitis, pyrexia, cough, epistaxis, nasopharyngitis, diarrhoea, vomiting, constipation, otitis media, dysuria, urinary retention, blurred vision, angioedema, paraesthesia, dystonia, oculogyric crisis, myoclonus, extrapyramidal symptoms.

Drug Interactions

Possible additive adverse CNS effects w/ CNS depressants (e.g. sedatives, tranquilizers).

Route of Administration

Oral

Dosage

As directed by the physician