Indications

Treatment of Hypertension, Treatment of Angina, Treatment of Arrhythmia, Prevention of Heart attack, Prevention of Migraine

Contraindication

Sick sinus syndrome, severe bradycardia, 2nd or 3rd degree AV block, uncompensated cardiac failure, severe asthma or COPD, cardiogenic shock, untreated pheochromocytoma, metabolic acidosis, severe peripheral circulatory disease.

Special Precautions

Patients w/ inadequate cardiac function, well-compensated heart failure, bronchospastic disease, DM, hyperthyroidism. Patients undergoing major surgery involving general anaesth. May mask symptoms of hypoglycaemia and hyperthyroidism. Avoid abrupt withdrawal as it may exacerbate angina symptoms and/or precipitate MI and ventricular arrhythmias or may precipitate thyroid storm. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor ECG, heart rate and BP.

Side Effects

Bradycardia, hypotension, chest pain, oedema, heart failure. Dizziness, sweating, fatigue, insomnia, lethargy, confusion, mental impairment, depression, headache, nightmares. Constipation, diarrhoea, nausea, impotence, cold extremities.

Drug Interactions

Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive w/ Ca channel blockers, hydralazine, methyldopa. Increased risk of bradycardia and heart block w/ verapamil and diltiazem. May decrease hypotensive effects w/ NSAIDs (e.g. indometacin). Enhanced bradycardic effect w/ disopyramide, amiodarone or digitalis glycosides. May exacerbate rebound HTN upon discontinuance of clonidine treatment.

Route of Administration

Oral

Dosage

As directed by the physician