Indications

Antibiotic

Contraindication

Hypersensitivity to clindamycin or lincomycin.

Special Precautions

Patient w/ history of GI disease particularly colitis, atopic individuals. Not intended for the treatment of CNS infections. Severe renal and/or hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor CBC, liver and renal function during prolonged therapy.

Side Effects

Nausea, vomiting, abdominal pain or cramps, taste disturbances, oesophagitis, oesophageal ulceration, rashes, urticaria, erythema multiforme, Stevens-Johnson syndrome, drug rash w/ eosinophilia and systemic symptoms (DRESS), exfoliative and vesiculobullous dermatitis, leucopenia, agranulocytosis, eosinophilia, thrombocytopenia, polyarthritis, renal dysfunction (e.g. azotemia, oliguria, proteinuria), local irritation, skin dryness, contact dermatitis, cervicitis, vaginitis, vag candidiasis, vulvovaginal irritation, sterile abscess and thrombophlebitis.

Drug Interactions

May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).

Route of Administration

Oral

Dosage

As directed by the physician