Indications

Antibiotic

Contraindication

Hypersensitivity to amoxicillin and other penicillins.

Special Precautions

Patient w/ history of β-lactam allergy, infectious mononucleosis. Renal impairment. Pregnancy and lactation. Patient Counselling Maintain adequate fluid intake and urinary output. Monitoring Parameters Monitor renal, hepatic, and haematologic functions; signs of anaphylaxis during 1st dose.

Side Effects

Nausea, vomiting, diarrhoea, black hairy tongue, serum sickness-like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalised exanthematous pustulosis, hypersensitivity vasculitis, urticaria, increased AST and ALT, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, crystalluria, anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leucopenia, agranulocytosis. Rarely, reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioural changes, dizziness, tooth discolouration.

Drug Interactions

May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin.

Route of Administration

Oral

Dosage

As directed by the physician