Indications

Type 2 DM.

Contraindication

Hypersensitivity to gliclazide, other sulfonylureas or sulfonamides. Type 1 DM, diabetic ketoacidosis, diabetic pre-coma and coma. Concomitant use w/ miconazole. Severe renal and hepatic impairment. Pregnancy and lactation.

Special Precautions

Patient w/ G6PD deficiency. Patient exposed to stress (e.g. trauma, infection, surgery). Mild to moderate hepatic and renal impairment. Patient Counselling Adhere strictly to diabetic diet. Monitoring Parameters Monitor fasting blood glucose, glycosylated Hb, signs and symptoms of hypoglycaemia.

Side Effects

Hypoglycaemia, GI disturbances (e.g. diarrhoea, constipation, gastroenteritis, abdominal pain), HTN, angina, headache, dizziness, skin disorder, back pain, arthralgia, weakness, bronchitis, rhinitis, pharyngitis, upper resp infection, viral infection.

Drug Interactions

May increase hypoglycaemic effect w/ phenylbutazone. Potentiation of blood glucose lowering effect w/ other antidiabetics (e.g. acarbose, insulins, metformin), β-blockers, ACE inhibitors, H2-receptor antagonists, MAOIs, sulfonamides, clarithromycin and NSAIDs. Chlorpromazine, glucocorticoids, ritodrine, salbutamol and terbutaline may cause increases in blood glucose levels. May diminish hypoglycaemic effect w/ danazol. May increase anticoagulant effect of warfarin.

Route of Administration

Oral

Dosage

As directed by the physician