Indications

Ondansetron is an antiemetic medicine used to treat and prevent nausea and vomiting caused by surgery, cancer medicines (chemotherapy) or radiation therapy.

Contraindication

Patients w/ congenital long QT syndrome. Concomitant use of apomorphine.

Special Precautions

May mask progressive ileus and/or gastric distension. Severe hepatic impairment. Pregnancy and lactation. Monitoring Parameters ECG monitoring of patients w/ electrolytes abnormalities e.g. hypomagnesaemia or hypokalaemia, CHF or bradyarrhythmias and on medication that can prolong QT interval.

Side Effects

Headache, hiccups, flushing or warmth sensation, constipation, rash, urticaria; seizures and movement disorders including extrapyramidal symptoms (e.g. dyskinesia, dystonia, oculogyric crisis). IV: Inj site reaction, dizziness, transient visual disturbances (blurred vision or very rarely, transient blindness). Supp: Local burning sensation; transient liver enzyme elevation. Rarely, anaphylaxis, bradycardia and tachycardia, arrhythmia, chest pain, hypotension, transient ECG changes.

Drug Interactions

May reduce analgesic effect of tramadol. Rifampicin and other CYP3A4 inducers may reduce levels/effects of ondansetron. Concomitant use of QT-prolonging agents (e.g. antiarrhythmics) may cause additive prolongation of QT interval. May increase the risk of arrhythmias w/ cardiotoxic drugs (e.g. anthracyclines).

Route of Administration

Oral, Injection

Dosage

As directed by the physician