Indications

Antihypertensive, Chronic stable angina

Contraindication

Severe hypotension, shock (including cardiogenic shock), obstruction of the outflow tract of the left ventricle (e.g. aortic stenosis), haemodynamically unstable heart failure after acute MI.

Special Precautions

Patients w/ cardiac failure. Hepatic and renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive and operate machinery. Monitoring Parameters Monitor BP and heart rate.

Side Effects

Somnolence, dizziness, headache, ankle swelling, oedema, flushing, fatigue, palpitations, abdominal pain, nausea. Rarely, confusion, rash, gingival hyperplasia, muscle cramps, dyspnoea.

Drug Interactions

Plasma concentrations may be elevated w/ CYP3A4 inhibitors (e.g. azole antifungals, ritonavir). Concomitant therapy w/ simvastatin may increase risk of myopathy including rhabdomyolysis. May increase ciclosporin plasma levels and conivaptan.

Route of Administration

Oral

Dosage

As directed by the physician