Indications

Prophylaxis of thromboembolic disorders, Acute coronary syndrome

Contraindication

Active pathological bleeding (e.g. peptic ulcer or intracranial haemorrhage).

Special Precautions

Patient at risk of increased bleeding from trauma, surgery or other pathological conditions. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor for signs of bleeding; Hb and haematocrit periodically.

Side Effects

Haematoma, epistaxis, diarrhoea, dyspepsia, abdominal pain, bruising, bleeding at puncture site. Rarely, Stevens-Johnson syndrome, erythema multiforme, serum sickness, interstitial pneumonitis, lichen planus, myalgia.

Drug Interactions

Increased risk of bleeding w/ anticoagulants, other antiplatelets, NSAIDs, SSRIs, serotonin norepinephrine reuptake inhibitors. May reduce antiplatelet effect w/ CYP2C19 inhibitor including PPI (e.g. esomeprazole, omeprazole).

Route of Administration

Oral

Dosage

As directed by the physician