Indications

Antibiotic

Contraindication

Hypersensitivity to penicillins. History of severe immediate hypersensitivity reaction to another β-lactam agent (e.g. cephalosporins, carbapenem or monobactam), history of cholestatic jaundice/hepatic dysfunction associated w/ amoxicillin and clavulanic acid therapy.

Special Precautions

Patient w/ mononucleosis. Renal and hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Periodically monitor renal, hepatic and haematologic function. Monitor for signs of anaphylaxis during 1st dose.

Side Effects

Diarrhoea/loose stools, Clostridium difficile-associated diarrhoea, pseudomembranous colitis, nausea, vomiting, skin rashes, urticaria, vaginitis.

Drug Interactions

May increase plasma concentration of amoxicillin w/ probenecid. May increase allergic or hypersensitivity reaction w/ concomitant use of allopurinol and amoxicillin. May reduce efficacy of oral oestrogen/progesterone contraceptives.

Route of Administration

Injection

Dosage

As directed by the physician