Indications

Hyperlipidaemia, Prophylaxis of cardiovascular events in high-risk patients

Contraindication

Active liver disease or unexplained persistent elevated serum transaminases. Severe renal impairment. Concomitant use w/ ciclosporin and gemfibrozil. Pregnancy and lactation.

Special Precautions

Patients w/ predisposing factors for myopathy (e.g. untreated hypothyroidism, renal impairment), history of chronic liver disease and alcoholism. Monitoring Parameters Monitor creatine kinase (CK) periodically and LFT. Discontinue treatment if there is significant or persistent increase in CK levels, serum aminotransferase levels or evidence of myopathy.

Side Effects

Headache, dizziness, constipation, nausea, vomiting, abdominal pain, myalgia, chest pain, peripheral oedema, depression, insomnia, rash, paraesthesia, asthenia, abnormal LFT, elevated serum transaminase levels.

Drug Interactions

May increase serum levels of warfarin and oral contraceptives. May increase serum levels w/ itraconazole, HIV protease inhibitors. May decrease serum levels w/ erythromycin and antacids. May increase risk of myopathy w/ fenofibrate, niacin.

Route of Administration

Oral

Dosage

As directed by the physician