Indications

Type 2 DM.

Contraindication

Hypersensitivity to glimepiride, other sulfonylureas or sulfonamides. Diabetic ketoacidosis w/ or w/o coma. Severe renal or hepatic impairment.

Special Precautions

Patient w/ G6PD deficiency, autonomic neuropathy, thyroid or adrenocortical insufficiency. Patient exposed to stress (e.g. fever, trauma, infection, surgery). Mild to moderate hepatic or renal impairment. Elderly, debilitated and malnourished patients. Pregnancy and lactation. Patient Counselling Adhere to diet and exercise regimen. Monitoring Parameters Monitor blood glucose, glycosylated Hb level, signs and symptoms of hypoglycaemia.

Side Effects

Dizziness, headache, nausea, increased serum ALT, flu-like symptoms, accidental injury, dyspnoea, fall in BP, shock, thrombocytopenia and thrombocytopenic purpura.

Drug Interactions

Salicylates, sulfonamides, chloramphenicol, clarithromycin, coumarin anticoagulants, probenecid, CYP2C9 inhibitors, fibric acid derivatives, disopyramide, fluoxetine, quinolones, ACE inhibitors, MAOIs and β-blockers may potentiate the hypoglycaemic action of glimepiride. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, phenytoin, nicotinic acid, sympathomimetics and CYP2C9 inducers may reduce hypoglycaemic effect of glimepiride. Reduced plasma concentration w/ colesevelam.

Route of Administration

Oral

Dosage

As directed by the physician