Indications

Antibiotic

Contraindication

Hypersensitivity to cefotaxime or other cephalosporins.

Special Precautions

Patient w/ history of penicillin allergy and colitis. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor renal function, CBC w/ differential. Observe for signs and symptoms of anaphylaxis during 1st dose.

Side Effects

Rash (maculopapular or erythematous), pruritus, fever, eosinophilia; inflammation, phlebitis, thrombophlebitis (IV); pain, induration, tenderness at inj site (IM); anorexia, diarrhoea, nausea, vomiting, abdominal pain; transient neutropenia, granulocytopenia, leucopenia, eosinophilia or thrombocytopenia; transient increases in BUN and/or serum creatinine concentrations and interstitial nephritis; hepatitis, jaundice, cholestasis; transient increases in serum AST, ALT, LDH, γ-GT, bilirubin, and alkaline phosphatase concentrations; headache, agitation, confusion, fatigue, nocturnal perspiration. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.

Drug Interactions

Increased risk of nephrotoxicity w/ aminoglycosides. Increased serum concentration w/ probenecid.

Route of Administration

Parenteral

Dosage

As directed by the physician