Indications

Hypertension, Heart failure, Hypertension

Contraindication

History of angioedema due to previous treatment w/ ACE inhibitors. Hereditary or idiopathic angioedema. Pregnancy.

Special Precautions

Patients w/ bilateral renal artery stenosis or a single kidney w/ unilateral renal artery stenosis, and w/ collagen vascular disease; aortic or mitral valve stenosis. Pre-existing renal insufficiency. Lactation. Monitoring Parameters Monitor BP, and K levels. Correct volume depletion prior to treatment.

Side Effects

Hypotension, dizziness, headache, fever, vertigo, fatigue, insomnia, peripheral neuropathy, nervousness, persistent dry cough, taste disturbances, rash, conjunctivitis, tachycardia, muscle cramps, nausea and vomiting, diarrhoea, skin reactions, dysgeusia, neutropenia, renal impairment or failure.

Drug Interactions

May potentiate hypotensive action w/ diuretics, other antihypertensives, TCAs, nitrates or anaesth. Concomitant admin w/ lithium carbonate may cause lithium toxicity. Increased risk of renal impairment w/ NSAIDs. May increase hyperkalaemic effect w/ K-sparing diuretics and supplements.

Route of Administration

Oral

Dosage

As directed by the physician